A number of high profile innovations have been created in Sub-Saharan Africa. In this paper, we examine the mechanisms associated with the development, deployment, diffusion, and export of SSA-originated innovations. The paper gives special consideration to the relative roles and contributions of local and outside resources in the creation and deployment of innovations in SSA economies. A key focus of the article is on the roles of local infrastructural facilities, systems and services in affecting the diffusion of SSA-originated innovations. Also discussed are the features of SSA-originated innovations that explain the diffusion rates. It provides a detailed analysis and description of the key characteristics of SSA-originated innovations that can increase the possibility of being internationalized or exported to other countries. Finally, we analyze how such mechanisms vary across large and small scale innovations.