Research partnerships are not a new organizational form, but since the mid 1980s the US government, like other national governments, has provided a favorable environment for them to flourish. The purpose of this paper is to address the question: What is the economic foundation upon which public support of research partnerships in the USA is based? In addition, given that foundation: What additional information is needed to increase the efficacy of the current policy environment? We summarize the relevant literature and find that as a whole, the theoretical literature makes clear that research partnerships are a socially beneficial organizational form once formed. However, more empirical research is needed of a different type that has occupied the journals to date. We offer an agenda for such research that will complement the policy process.