The rate of substitution of L by a chloride ion or acetonitrile in cis-[Ru(bpy)2 (L)(X)]+ (X = NO3; L = pyridine, acetonitrile ; bpy = 2,2'-bipyridine) in low polarity so[...]

Many chemical carcinogens and their in vivo activated metabolites react readily with genomic DNA, and form covalently bound carcinogen-DNA adducts. Clinically, carcinogen[...]

The exploration of freshwater ascomycetes, which have undergone only limited investigation, may provide opportunities both to characterize new genera/species of fungi and[...]

From the rice-based culture of Malbranchea flavorosea, three new compounds namely flavoroseoside B (5-desoxy-5-chloro-flavoroseoside) (2), 4-hydroxy-2-O-a-ribofuranosyl-5[...]

Two new species of freshwater ascomycetes belonging to the genus Lindgomyces (Pleosporales, Dothideomycetes) are described and illustrated from submerged wood in North Ca[...]

We recently reported two unexplored reactivities of alkynes and azides. The first method reacts nucleophilic alkynes and electrophilic azides to synthesize sulfonyl-subst[...]

The human cannabinoid-1 (CB1) receptor is a Class A, rhodopsin-like G protein-coupled receptor (GPCR). CB1 is found primarily in the central nervous system (CNS) where it[...]

This article describes the development of a new fluorescent-engineered human calmodulin, hCaM M124C–mBBr, useful in the identification of potential calmodulin (CaM) inhib[...]

Objectives: To determine the relative quantities of two hepatotoxic pyrrolizidine alkaloids, symphytine and echimidine, in teas prepared from comfrey leaves (Symphytum of[...]

Bacillus subtilis is a rod shaped, aerobic, endospore forming gram-positive bacterium. B. subtilis is used as a model organism to study cell differentiation during sporul[...]

Ginseng has been used for thousands of years as an herbal remedy for many common ailments. Ginsenosides from ginseng have shown a wide range of biological effects, includ[...]

The role of neo-angiogenesis in prostate cancer (PCA) growth and metastasis is well established, but the development of effective and non-toxic pharmacological inhibitors[...]

Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non[...]

Background: Thevetia peruviana (Pers.) K. Schum or Cascabela peruviana (L.) Lippold (commonly known as ayoyote, codo de fraile, lucky nut, or yellow oleander), native to [...]

The potential of fungal endophytes to alter or contribute to plant chemistry and biology has been the topic of a great deal of recent interest. For plants that are used m[...]

Topical preparations of Anemopsis californica have been used by Native American tribes in the southwestern United States and northern Mexico to treat inflammation and inf[...]

A recently isolated natural compound, Petaslignolide A, from the leaves of Petasites japonicas, has shown to be an effective neuroprotecting agent because of its antioxid[...]

A rapid approach to the 16S rRNA gene (16S rDNA)-based bacterial identification has been developed that combines uracil-DNA-glycosylase (UDG)-mediated base-specific fragm[...]

Plants in the genus Euphorbia produce a wide variety of pharmacologically active diterpenoids with anticancer, multidrug resistance reversal, and antiviral properties. So[...]

Natural products have played a significant role in the drug discovery especially in the area of cancer. Over the period of 1940-2010, 50% of the small molecules introduce[...]

Bacillus subtilis is an industrially important organism because of its ability to produce enzymes and antibiotics on a commercial scale. It is considered the Gram positiv[...]

A critical challenge in the study of botanical natural products is the difficulty of identifying multiple compounds that may contribute additively, synergistically, or an[...]

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Enzymes have transformed our understanding of chemistry, particularly through advancements in biocatalysis, which enable the sustainable reproduction of classical organic[...]

Synthetic biological approaches, such as site-directed biosynthesis, have contributed to the expansion of the chemical space of natural products, making possible the bios[...]