Many chemical carcinogens and their in vivo activated metabolites react readily with genomic DNA, and form covalently bound carcinogen-DNA adducts. Clinically, carcinogen[...]

Although the UV absorbance of DNA at 260 nm has been recognized as a standard method for DNA quantitation, there are limitations of using UV spectrometry to determine the[...]

The discovery of microRNAs (miRNAs) and their abilities to regulate in vivo protein synthesis have led to growing interests in miRNA research. Due to their functions on r[...]

In the absence of high vacuum, the mobility of ions in an electric field is dependent on the charge, mass, shape and size of the ions. To achieve accurate calibration for[...]

The advantages of combining qualitative and quantitative analysis on a single analytical technique have further extended the applications of matrix-assisted laser desorpt[...]

Sample preparation for matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) of DNA is critical for obtaining high quality mass spectra. Sample impur[...]

Whole cell mass spectroscopy (WCMS) is a method that has gain popularity in the last decade. WCMS saves time by omitting extensive sample preparation for the mass spectra[...]