Epichloid endophytes are well known symbionts of many cool-season grasses that may alleviate environmental stresses for their hosts. For example, endophytes produce alkal[...]

Many pooid grasses (Poaceae) harbor Epichloë species (Hypocreales), endophytic fungi that often produce toxic alkaloids which may provide anti-insect protection for their[...]

Despite their minute biomass, microbial symbionts of plants potentially alter herbivory, diversity and community structure. Infection of grasses by asexual endophytic fun[...]

Neotyphodium endophytes are asexual, seed-borne fungal symbionts that are thought to interact mutualistically with their grass hosts. Benefits include increased growth, r[...]

The preparation and biological activity of various structural analogs of the malbrancheamides are disclosed. The impact of indole chlorination, C-12a relative stereochemi[...]

The safety and efficacy of kratom (Mitragyna speciosa) for treatment of pain is highly controversial. Kratom produces more than 40 structurally related alkaloids, but mos[...]

Bioactivity-directed fractionation of the organic extracts of two filamentous fungi of the Bionectriaceae, strains MSX 64546 and MSX 59553 from the Mycosynthetix library,[...]

The number of sequenced genomes has greatly increased over the years, leading to the creation of huge publicly available genomic databases. Thanks to these databases, gen[...]

Most plants harbor microbial symbionts, which often affect host performance and fitness. Endophytic Epichloë species are systemic fungal microbial symbionts of many cool-[...]

Endophyte-produced alkaloids may negatively affect herbivores. They may also cascade up the food web and affect the third trophic level, predators and parasites of herbiv[...]

Some cool-season pooid grasses partner with symbiotic fungal endophytes in the Epichloë genus for defense against insect herbivores via fungal alkaloids. Poa alsodes, Nor[...]

Goldenseal (Hydrastis canadensis L.) is used to combat inflammation and infection. Its antibacterial activity in vitro has been attributed to its alkaloids, the most abun[...]

The endophyte presence and diversity in natural populations of Poa alsodes were evaluated along a latitudinal transect from the southern distribution range in North Carol[...]

Many consumers are turning to kratom (Mitragyna speciosa) to self-manage pain and opioid addiction. In the United States, an array of capsules, powders, and loose-leaf kr[...]

Verticillins are a group of epipolythiodioxopiperazine alkaloids that have displayed potent cytotoxicity. To evaluate their potential further, a larger supply of these co[...]

Verticillin A is a natural product isolated from fungal cultures and has displayed potent antibiotic, antiviral, nematocidal, and anticancer properties in vitro. While in[...]

The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S[...]

The study presented herein constitutes an extensive investigation of constituents in Hydrastis canadensis L. (Ranunculaceae) leaves. It describes the isolation and identi[...]

Natural products research remains a fertile source for drug discovery due to the complexity, chemical diversity and biological activity of compounds discovered from natur[...]

Two new sesquiterpene alkaloids, 1(beta)hydroxy-2(beta)5a,11-triacetoxy-7(beta)nicotinoyl-8(beta)benzoyl-dihydroagarofuran (1), and 1(beta)5a,11-triacetoxy-7(beta)nicotin[...]

Objective: The heterogeneity of soft tissue sarcoma (STS) represents a major challenge for the development of effective therapeutics. Comprised of over 50 different histo[...]