Many chemical carcinogens and their in vivo activated metabolites react readily with genomic DNA, and form covalently bound carcinogen-DNA adducts. Clinically, carcinogen[...]

The Cytochrome P450 family is a class of enzymes responsible for the breakdown of about 75% of the drugs that are administered (18). The 2E1 isoform of this family is kno[...]

Two new species of freshwater ascomycetes belonging to the genus Lindgomyces (Pleosporales, Dothideomycetes) are described and illustrated from submerged wood in North Ca[...]

We recently reported two unexplored reactivities of alkynes and azides. The first method reacts nucleophilic alkynes and electrophilic azides to synthesize sulfonyl-subst[...]

Since the pharmaceutical industry has experienced a decline in output over the past decade, natural products research has regained interest. The complexity and molecular [...]

Utilizing archaeometric methods, we evaluate the nature of production of feasting events in the ancient Wari state (600–1000 CE). Specifically, we focus on the fabricatio[...]

Atoms are lonely hearts that are constantly in search of partners to bring stability to their lives—at Least that's the premise of our Atomic Dating Game, a chemistry act[...]

A rapid approach to the 16S rRNA gene (16S rDNA)-based bacterial identification has been developed that combines uracil-DNA-glycosylase (UDG)-mediated base-specific fragm[...]

Natural products have played a significant role in the drug discovery especially in the area of cancer. Over the period of 1940-2010, 50% of the small molecules introduce[...]

Sixteen polyketides belonging to diverse structural classes, including monomeric/dimeric tetrahydroxanthones and resorcylic acid lactones, were isolated from an organic e[...]

Poster presented on October 9, 2020 at the STELLA (Science, Technology, and Engineering Library Leaders in Action) biennial unconference. Science and instructional librar[...]

For the development of specific immunological assays, the binding of a specific antibody (Ab) to the target antigen (Ag) has to be relatively strong. In this study, we ha[...]

Plants are valuable sources of medicinal compounds and their use for healing is well known from ancient times. Natural drugs obtained from plants represent about 25% of t[...]

Although the UV absorbance of DNA at 260 nm has been recognized as a standard method for DNA quantitation, there are limitations of using UV spectrometry to determine the[...]

In this study, we compared the sensitivity of two different detection methods for quantitative polymerase chain reaction (PCR). Various amounts of a 75 mer single-strande[...]

The purpose of Phase I of this research was to construct two homology models, one each inactive (R state) and active (R* state), of the orexin-1 receptor (ox1r). The ox1r[...]

""Echinacea" and "Spilanthes" are popular over-the-counter herbal supplements derived from raw tissue or tissue extracts from plants such as Echinacea purpurea and Spilan[...]

The use of scattering experiments in atmospheric studies has proved useful in understanding the dynamics of the catalytic ozone destruction cycle. By using millimeter and[...]

As part of an ongoing investigation into the pharmaceutical potential of filamentous fungi, two new drimane meroterpenoids were discovered, which showed moderate cytotoxi[...]

GPR35, a G protein-coupled receptor (GPCR), was discovered and specified as an orphan receptor in 1998. GPR35 has been described as a prospective therapeutic target as a [...]

This thesis is focused on the development of some important informatics methods that will assist drug discovery scientists in their pursuit of novel molecular structures,[...]

Chiral molecules play a vital role in supporting biologically effective drugs. Consequently, a majority of pharmaceutical companies seek to isolate the enantiomers of mol[...]

Line of Inquiry 1: Characterizing Chemistry Instructors’ Approaches Toward Teaching with RepresentationsLearning chemistry requires both, mastery of abstract concepts and[...]

Transition metal-dioxygen (O2) interactions are of great importance in biological and chemical transformations involving dioxygen binding, activation, or reduction. In th[...]

The oxidation of transition metals such as manganese and copper by dioxygen (O2) is of great interest to chemists and biochemists for fundamental and practical reasons. I[...]